Therapeutic Efficacy of Home-Use Photobiomodulation Devices: A Systematic Literature Review.

Concusion: Home-use PBM devices appear to mediate effective, safe treatments in a variety of conditions that require frequent applications. 

Light-emitting diode therapy reduces persistent inflammatory pain: Role of interleukin 10 and antioxidant enzymes.

Conclusions: These data contribute to the understanding of the neurobiological mechanisms involved in the therapeutic effect of LEDT as well as provides additional support for its use in the treatment of painful conditions of inflammatory etiology.

Conclusions: Optimization of light parameters allows R/NIR to act as an anti-inflammatory agent in a wide range of medical applications..

Research on 470nm Blue Light

Research on 660nm Red Light

Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia.

Extract: Our results show that low-level laser therapy was more efficient in reducing pain and improving cartilage thickness through biochemical changes.

Results: All patients completed their LED regimens (4 requiring 1 regimen, 5 requiring a second). Follow-up periods were from 3 to 8 months, except in two patients who were lost to follow-up. Clearance rates at the end of the follow-up period ranged from 60% to 100%. Satisfaction was universally very high.

Conclusions: The antiinflammatory effects of LED energy at 830 nm and 633 nm have been well documented, as has their use in wound healing. LED phototherapy is easy to apply, pain free and side-effect free, and is well tolerated by patients of all skin types. The promising results of this preliminary study warrant a proper controlled double-blind study with a larger patient population.

Nogier frequencies are pulse rates used with Low Light Therapy research.
  • The naked eye can see up to 50 Hz. 
  • Different devices/equipment contains varying abilities to produce the below, extremely fast pulse rates.
The majority of research listed will contain at least one of the below pulse rates.

 Nogier Frequecies: Auricular Acupuncture



Scientific Links relating to Light Therapy
Red 660nm, Near-Infrared 850nm or Blue 470nm
are listed separately 
NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea (
NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea
NASA LEDs stimulate the basic energy processes in the mitochondria (energy compartments) of each cell, particularly when near-infrared light is used to activate the colour sensitive chemicals (chromophores, cytochrome systems) inside. Optimal LED wavelengths include 680, 730 and 880 nm and our laboratory has improved the healing of wounds in laboratory animals by using both NASA LED light and hyperbaric oxygen. Furthermore, DNA synthesis in fibroblasts and muscle cells has been quintupled using NASA LED light alone, in a single application combining 680, 730 and 880 nm each at 4 Joules per centimeter squared
Effects of low-power light therapy on wound healing: LASER x LED*
The biological effects promoted were reduction of inflammatory cells, increased proliferation of fibroblasts, stimulation of collagen synthesis, angiogenesis inducement and granulation tissue formation. It was noted in a study that the dose of 4 J/cm2 was more effective than 8 J/cm2 .14 Furthermore, doses of 10 and 16 J/cm2 promoted inhibitory effects.20,25,29,34
Clinical and experimental applications of NIR-LED photobiomodulation
Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light.
Effect of NASA light-emitting diode irradiation on wound healing
Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.
Infrared therapy for chronic low back pain: A randomized, controlled trial.
Recently, infrared (IR) therapy has been developed, which has shown improved wound healing (79), relief of arthritic knee pain (10), increased endorphin levels (11) and bioactivation of neuromodulators (1113). 
Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subjects
Results: Transmission electron microscopy revealed mild fibroplastic changes in fibroblasts, with no acute inflammatory changes throughout the treatment session. Qualitative PCR showed the presence of both Th-1 and Th-2 T-cells, and quantitative PCR showed an increase in the numbers of both types of skin-homing T-cells, much more so for Th-2 than for Th-1.
Conclusions: Visible red LED irradiation appears to activate the skin-homing immune system.
Evidence of changes in sural nerve conduction mediated by light emitting diode irradiation
Based on these results, it can be concluded that LED irradiation, applied to intact skin at the described irradiation parameters, produces an immediate and localized effect upon conduction characteristics in underlying nerves. Therefore, the outcome of this in vivo experiment yields a potential explanation for pain relief induced by LED.
Mechanisms of Low Level Light Therapy
The use of low levels of visible or near-infrared (NIR) light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing tissue damage has been known for almost forty years since the invention of lasers.
Role of Low-Level Laser Therapy in Neurorehabilitation
In recent years, LLLT has become an increasingly mainstream modality, especially in the areas of physical medicine and rehabilitation. At first used mainly for wound healing and pain relief, the medical applications of LLLT have broadened to include diseases such as stroke, myocardial infarction, and degenerative or traumatic brain disorders. This review will cover the mechanisms of LLLT that operate both on a cellular and a tissue level.
An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo
Low level laser therapy (LLLT) is frequently used in the treatment of wounds, soft tissue injury and in pain management. The exact penetration depth of LLLT in human tissue remains unspecified. Similar uncertainty regarding penetration depth arises in treating animals. This study was designed to test the hypothesis that transmission of LLLT in horses is increased by clipping the hair and/or by cleaning the area to be treated with alcohol, but is unaffected by coat colour.
Use of laser light to treat certain lesions in standardbreds
Of 8 horses treated for plantar desmitis, 87.5% had similar or faster final and last-quarter times, and raced in similar or higher classes after treatment. Of 30 horses treated for pharyngeal lymphoid hyperplasia, 80% had similar or faster final race times, 90% had similar or faster last-quarter times, and 70% raced in similar or higher classes after treatment.
Is light-emitting diode phototherapy (LED-LLLT) really effective?
Conclusions: Provided an LED phototherapy system has the correct wavelength for the target cells, delivers an appropriate power density and an adequate energy density, then it will be at least partly, if not significantly, effective. The use of LED-LLLT as an adjunct to conventional surgical or nonsurgical indications is an even more exciting prospect. LED-LLLT is here to stay.
The Use of NASA Light-Emitting Diode Near-Infrared Technology for Biostimulation
 An LED blanket device may be used for the prevention of bone and muscle atrophy in astronauts. The depth of near-infrared light penetration into human tissue has been measured spectroscopically.
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
This small feasibility study suggests that NIR-PBM may have utility for the treatment of depression and other psychiatric disorders and that double blind randomized placebo-controlled trials are indicated.
Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study 
This is the first report of high-powered NILT showing efficacy for depression. Multi-Watt NILT showed far greater efficacy and persistent benefit compared to low-power (
Effect of near-infrared light on in vitro cellular ATP production of osteoblasts and fibroblasts and on fracture healing with intramedullary fixation.
Conclusion: The study demonstrated an immediate increase in ATP production in vitro and an initial acceleration of callus formation in the fracture healing process, in the presence of NIR
Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures
Conclusions: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction
Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways 
these findings provide the first evidence that FIR confers a real and significant benefit on the preconditioning of BMSCs, and might lead to novel strategies for improving BMSC therapy for cardiac ischemia.
NASA Light Technology Successfully Reduces Cancer Patients Painful Side Effects from Radiation and Chemotherapy
A NASA technology originally developed for plant growth experiments on space shuttle missions has successfully reduced the painful side effects resulting from chemotherapy and radiation treatment in bone marrow and stem cell transplant patients.
US Department of Veteran Affairs - Research & Development - Can Light Therapy help the brain? 
Neuropsychological testing before the therapy and at several points thereafter showed gains in areas such as executive function, verbal learning, and memory. The study volunteers also reported better sleep and fewer PTSD symptoms.