Scientific Research on conditions relating to knee pain; degenerative osteoarthritis; meniscal pathology; Bouchard's and Heberden's osteoarthritis; chronic low back pain; Muscle and bone; wound healing; heart injury; optic nerves; ocular diseases; immune system; sural nerve; rehabilitation; Nogier frequencies; Laser vs LED; depression; anxiety; fracture; ischemic lesions; bone marrow; cardiac stem cells; kidney injury; spaceflight; cancer; cognitive rehabilitation; PTSD; osteoarthritis.NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea (marquette.edu)NASA Research - Medical applicationsExtract: Muscle and bone atrophy are well documented in astronauts, and various minor injuries occurring in space have been reported not to heal until landing on Earth. An LED blanket device may be used for the prevention of bone and muscle atrophy in astronauts. The depth of near-infrared light penetration into human tissue has been measured spectroscopically (Chance, et al., 1988). Spectra taken from the wrist flexor muscles in the forearm and muscles in the calf of the leg demonstrate that most of the light photons at wavelengths between 630-800 nm travel 23 cm through the surface tissue and muscle between input and exit at the photon detector. The light is absorbed by mitochondria where it stimulates energy metabolism in muscle and bone, as well as skin and subcutaneous tissue. Clinical and experimental applications of NIR-LED photobiomodulation Dr Harry T Whelan. Professor of Neurology, Pediatrics, and Hyperbaric Medicine http://www.ncbi.nlm.nih.gov/pubmed/16706690Extract: Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Extract: The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism in vitro, and accelerates cell and tissue repair in vivo. NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction. Effect of NASA light-emitting diode irradiation on wound healinghttp://www.ncbi.nlm.nih.gov/pubmed/11776448Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis. Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cellshttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544713/Conclusions: These findings indicate that near-infrared light photobiomodulation (670 nm) may be a noninvasive, inexpensive, and easy adjunctive therapy to help inhibit the development of ocular diseases induced by the activation of phagocytosis Infrared therapy for chronic low back pain: A randomied, controlled trialhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539004/Conclusion: The IR therapy unit used was demonstrated to be effective in reducing chronic low back pain, and no adverse effects were observed. Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subjectshttp://www.ncbi.nlm.nih.gov/pubmed/16641531 Conclusion: Visible red LED irradiation appears to activate the skin-homing immune system Evidence of changes in sural nerve conduction mediated by light emitting diode irradiationhttp://www.ncbi.nlm.nih.gov/pubmed/15895289Extract: Based on these results, it can be concluded that LED irradiation, applied to intact skin at the described irradiation parameters, produces an immediate and localized effect upon conduction characteristics in underlying nerves. Therefore, the outcome of this in vivo experiment yields a potential explanation for pain relief induced by LED. Mechanisms of Low Light Therapyhttp://www.photobiology.info/Hamblin.htmlExtract: The use of low levels of visible or near-infrared (NIR) light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing tissue damage has been known for almost forty years since the invention of lasers. Extract: Mitochondria are thought to be a likely site for the initial effects of light, leading to increased ATP production, modulation of reactive oxygen species, and induction of transcription factors. These effects in turn lead to increased cell proliferation and migration (particularly by fibroblasts), modulation in levels of cytokines, growth factors and inflammatory mediators, and increased tissue oxygenation. Role of Low-Level Laser Therapy in Neurorehabilitationhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065857/Extract: This review will cover the mechanisms of LLLT that operate both on a cellular and a tissue level. Mitochondria are thought to be the principal photoreceptors, and increased adenosine triphosphate, reactive oxygen species, intracellular calcium, and release of nitric oxide are the initial events. Activation of transcription factors then leads to expression of many protective, anti-apoptotic, anti-oxidant, and pro-proliferation gene products. Animal studies and human clinical trials of LLLT for indications with relevance to neurology, such as stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, will be covered.Extract Conclusion: We believe that the high benefit:risk ratio of LLLT should be better appreciated by medical professionals in the rehabilitation and physical medicine specialties. Nogier Frequecies: Auricular Acupuncture (As used in our Custom Controller) Additional Research articles:Effects of low-power light therapy on wound healing: LASER x LEDhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148276/
Extract Conclusion: The biological effects promoted by these therapeutic resources are similar and are related to the decrease in inflammatory cells, increased fibroblast proliferation, angiogenesis stimulation, formation of granulation tissue and increased collagen synthesis. In addition to these effects, the irradiation parameters are also similar between LED and LASER. Is light-emitting diode phototherapy (LED-LLLT) really effective?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799034/Extract: Among the clinical applications, non-healing wounds can be healed through restoring the collagenesis/collagenase imbalance in such examples, and ‘normal’ wounds heal faster and better. Pain, including postoperative pain, postoperative edema and many types of inflammation can be significantly reduced. The Use of NASA Light-Emitting Diode Near-Infrared Technology for Biostimulationhttps://ntrs.nasa.gov/search.jsp?R=20030001599Extract: NASA LEDs stimulate the basic energy processes in the mitochondria (energy compartments) of each cell, particularly when near-infrared light is used to activate the color sensitive chemicals (chromophores, cytochrome systems) inside. Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxietyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796659/Conclusion: This small feasibility study suggests that NIR-PBM may have utility for the treatment of depression and other psychiatric disorders and that double blind randomized placebo-controlled trials are indicated. Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Studyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627142/Conclusion: This is the first report of high-powered NILT showing efficacy for depression. Multi-Watt NILT showed far greater efficacy and persistent benefit compared to low-power ( Effect of near-infrared light on in vitro cellular ATP production of osteoblasts and fibroblasts and on fracture healing with intramedullary fixation.https://www.ncbi.nlm.nih.gov/pubmed/27857496Conclusion: The study demonstrated an immediate increase in ATP production in vitro and an initial acceleration of callus formation in the fracture healing process, in the presence of NIR Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedureshttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/Conclusion: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction. Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651919/Extract: Our findings highlight the novel insight that FIR preconditioning significantly promotes BMSC proliferation, migration, cell survival, and recovery against H2O2. In general, FIR radiation transfers energy to the human body and manifests a wide variety of biological effects, including improvement of ischemic lesions.
Extract: For example, red (630 nm) and near infrared (850 nm) light-emitting diodes enhance the migration of MSCs derived from rat bone marrow11–13. Other studies have demonstrated that a diode (Ga-As) laser of wavelength 804 nm promots the proliferation of BMSCs and cardiac stem cells14–16. Interestingly, preconditioning using this wavelength has exhibited a cardioprotective effect on myocardial ischemia/reperfusion (I/R) injury in vivo 16. Another study has suggested that postconditioning with FIR increases heme oxygenase-1 expression and protects against I/R injury in rat testes17.Extract: In the case of acute kidney injury, the overexpression of CXCR4 has been shown to enhance the repair ability of BMSCs, increasing the homing of BMSCs and increasing the release of cytokines22. In a case of skin injury repair, CXCR4 overexpression in BMSCs promoted wound healing in a SDF-1-expression-dependent manner23. NASA Light Technology Successfully Reduces Cancer Patients Painful Side Effects from Radiation and Chemotherapyhttps://www.nasa.gov/topics/nasalife/features/heals.htmlExtract: LEDs are light sources releasing energy in the form of photons. They release long wavelengths of light that stimulate cells to aid in healing. HEALS technology allows LED chips to function at their maximum irradiancy without emitting heat. NASA is interested in using HEALS technology for medical uses to improve healing in space and for long-term human spaceflight. US Department of Veteran Affairs - Research & Development - Can Light Therapy help the brain? https://www.research.va.gov/currents/spring2015/spring2015-7.cfmExtract: She believes light therapy can be a valuable adjunct to standard cognitive rehabilitation, which typically involves "exercising" the brain in various ways to take advantage of brain plasticity and forge new neural networks."The light-emitting diodes add something beyond what's currently available with cognitive rehabilitation therapy," says Naeser. "That's a very important therapy, but patients can go only so far with it. And in fact, most of the traumatic brain injury and PTSD cases that we've helped so far with LEDs on the head have been through cognitive rehabilitation therapy. These people still showed additional progress after the LED treatments. It's likely a combination of both methods would produce the best results." SHORT-TERM EFFICACY OF LOW-LEVEL LASER THERAPY IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED PLACEBO-CONTROLLED, DOUBLE-BLIND CLINICAL TRIAL - PubMed (nih.gov)https://pubmed.ncbi.nlm.nih.gov/27027049/Results: A significant improvement in pain and function was found in all the assessments applied to the laser group. On comparing the laser group with the placebo group, significant differences were found in the VNS-resting and Lequesne evaluations.Conclusion: Treatment with LLLT improves pain and function over the short term in patients with knee osteoarthritis.