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Photodynamic and photobiological effects of light-emitting diode (LED) therapy in dermatological disease: an update - PMC (nih.gov)Conclusion: PDT is an effective form of treatment for an increasing number of human conditions, ranging from cancer to several skin conditions. Benefit deriving from the use of light is known since ancient time, but only in the last decades of twentieth century, we witnessed the rapid expansion of knowledge and techniques. Recent improvements of the therapy are related especially to photosensitizer’s development and delivery systems. Nowadays, the use of LED-based devices represents the emerging and safest tool for the treatment of many conditions such as skin inflammatory conditions, aging, and disorders linked to hair growth. Although the use of LED in the treatment of hair disorders has now entered common practice, better controlled studies are still needed to corroborate its efficacy. Review of Literature on Low-level Laser Therapy Benefits for Nonpharmacological Pain Control in Chronic Pain and Osteoarthritis - PubMed (nih.gov)Conclusion: Based on current research, the utilization of LLLT for pain management and osteoarthritic conditions may be a complementary strategy used in clinical practice to provide symptom management for patients suffering from osteoarthritis and chronic pain. A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase - PMC (nih.gov)Conclusion: RLT and ELT are large-area and full-body treatment modalities for skin rejuvenation and improvements in skin feeling and skin complexion. The application of RLT and ELT provides a safe, non-ablative, non-thermal, atraumatic photobiomodulation treatment of skin tissue with high patient satisfaction rates. RLT and ELT can extend the spectrum of anti-aging treatment options available to patients looking for mild and pleasant light-only skin rejuvenation Photobiomodulation: The Clinical Applications of Low-Level Light TherapyPhotobiomodulation: The Clinical Applications of Low-Level Light Therapy - PubMed (nih.gov)Results: A reasonable body of clinical trial evidence exists to support the role of low-energy red/near-infrared light as a safe and effective method of skin rejuvenation, treatment of acne vulgaris and alopecia, and, especially, body contouring. Methodologic flaws, small patient cohorts, and industry funding mean there is ample scope to improve the quality of evidence. It remains unclear if light-emitting diode sources induce physiologic effects of compararable nature and magnitude to those of the laser-based systems used in most of the higher-quality studies. Efficacy of the LED Red Light Therapy in the Treatment of Temporomandibular Disorders: Double Blind Randomized Controlled TrialEfficacy of the LED Red Light Therapy in the Treatment of Temporomandibular Disorders: Double Blind Randomized Controlled Trial - PubMed (nih.gov)Results: The changes in the pain value and number of the tender muscles in both groups were highly significant, only placebo group less but with no significant differences.Conclusions: This study showed that red LED therapy could be useful in improving patient's symptoms regarding pain, clicking, and number of tender muscles. In addition, this study showed the importance of the psychological part of treatment of those patients. This trial is registered with TCTR20190406002. Effect of Repeated Low-Level Red-Light Therapy for Myopia Control in ChildrenEffect of Repeated Low-Level Red-Light Therapy for Myopia Control in Children - Ophthalmology (aaojournal.org)Extract: In conclusion, among Chinese children 8 to 13 years of age with myopia, RLRL therapy is an effective new alternative treatment for myopia control with good user acceptability and no documented functional or structural damage; however, further research with double-masking and placebo control is needed to understand its long-term efficacy and safety, rebound effects, optimal treatment strategies (wavelength, power, duration, and frequency of treatment), and potential underlying mechanisms. Low-level light therapy of the eye and brainLow-level light therapy of the eye and brain - PubMed (nih.gov)Extract: Recent research is reviewed that supports LLLT potential benefits in retinal disease, stroke, neurotrauma, neurodegeneration, and memory and mood disorders. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain. A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenationA study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation - PubMed (nih.gov)Results: Key profilometry results Sq, Sa, Sp and St showed significant differences at week 12 follow-up; 52% of subjects showed a 25%-50% improvement in photoaging scores by week 12; 81% of subjects reported a significant improvement in periorbital wrinkles on completion of follow-up.Conclusion: Omnilux combination red and near infrared LED therapy represents an effective and acceptable method of photo rejuvenation. Further study to optimize the parameters of treatment is required. Declining eyesight improved by looking at deep red lightDeclining eyesight improved by looking at deep red light | UCL News - UCL – University College LondonExtract: Professor Jeffery said: “Our study shows that it is possible to significantly improve vision that has declined in aged individuals using simple brief exposures to light wavelengths that recharge the energy system that has declined in the retina cells, rather like re-charging a battery.Morning exposure to deep red light improves declining eyesight -- ScienceDailyExtract: Professor Jeffery said: "Using a simple LED device once a week, recharges the energy system that has declined in the retina cells, rather like re-charging a battery."And morning exposure is absolutely key to achieving improvements in declining vision: as we have previously seen in flies, mitochondria have shifting work patterns and do not respond in the same way to light in the afternoon -- this study confirms this."For this study the light energy emitted by the LED torch was just 8mW/cm2, rather than 40mW/cm2, which they had previously used. This has the effect of dimming the light but does not affect the wavelength. While both energy levels are perfectly safe for the human eye, reducing the energy further is an additional benefit. Red Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball PlayersRed Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball Players - PMC (nih.gov)Conclusions: Our study confirmed the effectiveness of body irradiation with red light in improving the quality of sleep of elite female basketball players and offered a nonpharmacologic and noninvasive therapy to prevent sleep disorders after training. skin-homing T- cells in human subjects.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539004/Extract: LED phototherapy at 630nm increases local levels of skin-homing T- cells in human subjects. Effect of helium-neon and infrared laser irradiation on wound healing in rabbitshttps://www.ncbi.nlm.nih.gov/pubmed/2927230Extract: Thus, laser irradiation at 632.8 nm and 904 nm alone or in combination increased tensile strength during wound healing and may have released tissue factors into the systemic circulation that increased tensile strength on the opposite side as well.Light-Emitting Diodes (LEDs) in Dermatology (mdedge.com)
DermatologyExtract: obtain excellent outcomes in a variety of skin conditions. Safer than sunlight, this new low level light therapy allows for the treatment of patients without pain, downtime or side effectsExtract: Rapidly emerging areas in light-based therapy include the treatment of cellulite and hair loss. Both conditions are very prevalent for which acceptable treatment options are lacking
Use of laser light to treat certain lesions in standardbredsStudy into race times after Red Light Therapy treatment
https://www.ncbi.nlm.nih.gov/pubmed/6727856Extract: The final and last-quarter race times and racing classes for a group of Standardbreds were analyzed before and after infrared laser light treatment. These horses had either check ligament injuries, plantar desmitis or pharyngeal lymphoid hyperplasia. A 904-nm infrared laser was used to treat check ligaments at 146 Hz for 26 sec/cm2 of affected area, acute plantar desmitis at 73 Hz and chronic plantar desmitis at 292 Hz for 26 sec/cm2 of affected area, and pharyngeal lymphoid hyperplasia at 146 Hz for 5 minutes. Of 35 horses treated for check ligament injuries, 80% had similar or faster final race times, 68.6% had similar or faster last-quarter times, and 68.6% raced in similar or higher classes after treatment. Of 8 horses treated for plantar desmitis, 87.5% had similar or faster final and last-quarter times, and raced in similar or higher classes after treatment. Of 30 horses treated for pharyngeal lymphoid hyperplasia, 80% had similar or faster final race times, 90% had similar or faster last-quarter times, and 70% raced in similar or higher classes after treatment. Effect of NASA light-emitting diode irradiation on wound healing.
https://www.ncbi.nlm.nih.gov/pubmed/11776448
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis.Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.